Cytochrome p450 enzymes cyp2d6, 2c8, 3a4 and 3a5 metabolize hydroxychloroquine to n -desethylhydroxychloroquine.
Information about Chloroquine.
Since this drug is known to concentrate in the liverit should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs.
Radioactively tagged chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyesIt was retained in the ocular tissues for five months after the drug had been eliminated from the rest of the body 2There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant womenUsage of chloroquine during pregnancy should be avoided except in the suppression or treatment of malaria when in the judgment of the physician the benefit outweighs the potential risk to the fetus.
Every effort has been made to ensure that the information provided by Cerner MultumIncMultumis accurateup-to-dateand completebut no guarantee is made to that effectDrug information contained herein may be time sensitiveMultum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriateunless specifically indicated otherwiseMultum’s drug information does not endorse drugsdiagnose patients or recommend therapyMultum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to ?buy remeron serve consumers viewing this service as a supplement toand not a substitute forthe expertiseskillknowledge and judgment of healthcare practitionersThe absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safeeffective or appropriate for any given patientMultum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum providesThe information contained herein is not intended to cover all possible usesdirectionsprecautionswarningsdrug interactionsallergic reactionsor adverse effectsIf you have questions about the drugs you are takingcheck with your doctornurse or pharmacist.
Unless your doctor instructs you otherwisecontinue your normal diet while taking chloroquine phosphate.
Patients with history of epilepsy should be advised about the risk of chloroquine provoking seizures.
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