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This drug passes into breast milkDiscuss the risks and benefits with your doctor before breast-feeding.

If TOPROL-XL is used in the setting of pheochromocytomait should be given in combination with an alpha blockerand only after the alpha blocker has been initiatedAdministration of beta-blockers alone in the setting of pheochromocytoma has been associated with a paradoxical increase in blood pressure due to the attenuation of beta-mediated vasodilatation in skeletal muscle.

Digitalis glycosidesclonidinediltiazem and verapamil slow atrioventricular conduction and decrease heart rateConcomitant use with beta blockers can increase the risk of bradycardia.

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